The world's most infamous cartel boss Joaquin "El Chapo" Guzman has been found guilty in a US court of drug trafficking.
Jurors in a federal court in Brooklyn have found Guzman, 61, guilty on all 10 counts.
Attorney for the Eastern District of New York Richard Donoghue said he expected Guzman to receive life without parole when sentenced on June 25.
"It is a sentence from which there is no escape and no return," Donoghue told reporters on Tuesday.
Guzman, one of the major figures in Mexican drug wars that have roiled the country since 2006, was extradited to the US for trial in 2017 after he was arrested in Mexico the year before.
The man whose nickname means "Shorty" sat and showed no emotion while the verdict was read.
Once the jury left the room, he and wife Emma Coronel put their hands to their hearts and gave each other the thumbs up sign. His wife shed tears.
US prosecutors said Guzman trafficked tonnes of cocaine, heroin, marijuana and methamphetamine into the US over more than two decades, consolidating his power in Mexico through murders and wars with rival cartels.
In a statement after the verdict, lawyers for Guzman said they were "obviously disappointed" but respectful of the jury's decision.
"We were faced with extraordinary and unprecedented obstacles in defending Joaquin, including his detention in solitary confinement," the statement said.
A lawyer for Guzman said he would appeal the verdict.
Through evidence from more than a dozen former associates, jurors heard how the Sinaloa Cartel gained power amid the shifting allegiances of the Mexican drug trade in the 1990s, eventually coming to control almost the entire Pacific coast of Mexico.
They heard how Guzman made a name for himself in the 1980s as "El Rapido", the speedy one, by building cross-border tunnels that allowed him to move cocaine from Mexico into the United States faster than anyone else.
The witnesses described how he built a sophisticated organisation reminiscent of a multinational corporation, with fleets of planes and boats, detailed accounting ledgers and an encrypted electronic communication system run through secret computer servers in Canada.
A former bodyguard testified that he watched Guzman kill three rival drug cartel members, including one victim who he shot and then ordered to be buried even as he was still gasping for air.
The US Justice Department said in 2017 it sought forfeiture of more than $US14b ($A20b) in drug proceeds and illicit profits from Guzman.
The trial also featured extensive testimony about corruption in Mexico, most of it involving bribes to law enforcement, military and local government officials, so the cartel could carry out its day-to-day drug shipping operations undisturbed.
The most shocking allegation came from Guzman's former top aide Alex Cifuentes, who accused former Mexican president Enrique Pena Nieto of taking a $US100m ($A141m) bribe from Guzman. A spokesman for the ex-president has denied the claim.