Henrikh Mkhitaryan has marked his Roma debut with a goal as the hosts claimed their first Italian Serie A win under boss Paulo Fonseca by beating Sassuolo 4-2 at the Stadio Olimpico.
Roma raced into a 2-0 lead through Bryan Cristante's header in the 12th minute and an Edin Dzeko finish seven minutes later.
Mkhitaryan, on loan from Arsenal, struck a third on 22 minutes and Justin Kluivert made it 4-0 just after the half-hour mark.
Sassuolo replied after the break with two goals from Domenico Berardi, a 53rd-minute free-kick and a left-footed effort in the 72nd minute.
Krzysztof Piatek's 68th-minute penalty secured AC Milan a 1-0 win at Hellas Verona, who had Mariusz Stepinski sent off in the 21st minute.
Marco Giampaolo's Milan were also reduced to 10 men in added time, with Davide Calabria given his marching orders.
Lazio were beaten 2-1 at SPAL thanks to a stoppage-time strike from Jasmin Kurtic.
The visitors had led via Ciro Immobile's first-half penalty before Andrea Petagna's 63rd-minute leveller and the late effort by Kurtic.
While AC Milan, Roma and Lazio are seventh, eighth and ninth respectively in the Serie A table, Bologna are second after a second-half comeback saw them defeat 10-man Brescia 4-3 at Stadio Mario Rigamonti.
An early Alfredo Donnarumma brace put Brescia 2-0 up and after Mattia Bani's reply, Andrea Cistana's header made it 3-1 just before the interval.
Daniele Dessena was sent off three minutes into the second half and Bologna turned the match around thanks to a 56th-minute Rodrigo Palacio effort, a Stefano Sabelli own goal four minutes after that and a Riccardo Orsolini strike with 10 minutes to go.
Atalanta are sixth after emerging with a 2-1 victory from a dramatic conclusion to their match at Genoa.
Duvan Zapata struck the winner in the fifth minute of stoppage time, four minutes after Domenico Criscito had equalised with a penalty.
That spot-kick had cancelled out substitute Luis Muriel's effort in the 64th minute.
Also on Sunday, Luca Ceppitelli netted a first-half brace as Cagliari won 3-1 at Parma.
Antonino Barilla pulled a goal back for Parma just before the hour mark, with Giovanni Simeone then adding Cagliari's third.