The 89-year-old actress was previously nominated for the Outstanding Character Voice-Over Performance award in 2021, 2022 and 2023 and now in 2025 she has emerged victorious at last, beating off strong competition from Hank Azaria for The Simpsons, Maya Rudolph in Big Mouth, Alan Tudyk for Andor, Jeffrey Wright in What If...? and Invincible's Steven Yeun.
2025 Creative Arts Emmys presenter Craig Robinson accepted the award on behalf of Andrews, who did not attend the ceremony.
Andrews was previously nominated at the Emmys for her role as Lady Whistledown in Bridgerton in 2021 and 2022 and again in 2023 for Queen Charlotte.
Bridgerton premiered on Netflix in 2020 and Andrews previously revealed she had never met any of her co-stars.
She told the Today show: "You know I've never met the company in person. Of course, I see them on the show sometimes. But I do all my recording far, far away from them.
"I think it's gorgeous looking, and they're all wonderful in it and they're lovely people to work with. (Producer) Shonda Rhimes and the whole gang down, they're terrific. And I'm thrilled that they asked me."
Meanwhile, the top nominees were among the top winners on the first night of the 77th Creative Arts Emmy Awards in Los Angeles on Saturday, which was devoted to scripted programming and animation.
The Studio, starring Seth Rogen (who co-created it with longtime partner Evan Goldberg) won nine awards, followed by Colin Farrell's The Penguin with eight Emmys and psychological drama Severance, with six.
Severance had led the way with 27 nominations, The Penguin had 24 and The Studio tied for third with The White Lotus at 23.