The 73-year-old star first played the role of Luke Skywalker in the original movie A New Hope in 1977 but has no wish to return as the protagonist, as he would prefer franchise bosses to focus on the "future" with different characters at the heart of the stories.
"I am so grateful to George (Lucas) for letting me be a part of that back in the day, the humble days when George called Star Wars the most expensive low-budget movie ever made," Hamill said in an interview with ComicBook.com.
"We never expected it to become a permanent franchise and a part of pop culture like that. But my deal is, I had my time. I'm appreciative of that, but I think they should focus on the future and all the new characters."
Hamill's last significant appearance was as a force ghost in the 2019 sequel trilogy flick The Rise of Skywalker and he joked that it was impossible for him to return after the ghostly truth about his alter ego was revealed in the 2017 picture The Last Jedi.
"(I) disappeared in ('The Last Jedi'), I left my robes behind. And there's no way I'm gonna appear as a naked force ghost," he said.
Hamill in 2024 confessed that he felt the "heart was gone" from Star Wars following the tragic passing of his co-star Carrie Fisher, who portrayed Princess Leia, at the age of 60 from a sudden a cardiac arrest in 2016.
Recalling the moment he learnt of Fisher's death, he said: "My wife (Marilou York) came into the bedroom - she gets up earlier than I do - I was still asleep. She had tears rolling down her face saying that Carrie had ...
"It forever altered how I reacted to Star Wars in general. The heart was gone. I don't talk about it because I don't like reliving it."
Hamill also paid tribute to Fisher for bringing an "effortless feminism" to the sci-fi franchise by standing strong against the villainous Darth Vader and taking command of both Luke and Han Solo, played by Harrison Ford.
"She was tough, she was telling Darth Vader off to his face - she was not intimidated by Darth Vader in the slightest."