Toufik and Salim Hamze were gunned down as they sat in a red ute at Guildford, in Sydney's west, early on October 20, 2021 amid a spate of public gangland murders.
Salim, 18, who police believe was the target of the hit, died in the ute, while his 64-year-old father died later in hospital.
"The callous murders of father and son, Toufik and Salim Hamze, was one of the worst organised crime assassinations we've seen in Australia, in which an innocent man was caught up in the violence and depravity," State Crime Commander Assistant Commissioner Mick Fitzgerald said in a statement on Wednesday.
A 28-year-old man was arrested during raids at properties in western Sydney on Wednesday morning and is expected to be charged with two counts of murder and involvement in a criminal group.
Another man, a 29-year-old who was already in custody at a Goulburn jail, is expected to face the same charges.
Police last year released images of a suspect wileding a gun running towards the parked car. (HANDOUT/NSW POLICE)
Arrest warrants have been issued for another three men, all of whom are believed to be hiding out overseas.
Among those sought is 30-year-old Rafat Alameddine, the alleged leader of the Alameddine crime gang, along with alleged members John Ray Bayssari, 33, and Zaid Abdelhafez, 24.
Mr Fitzgerald said now was the time for the men to come home.
"As they will be no doubt aware, the arm of the law is far reaching – and there are no safe havens to hide," he said on Wednesday.
Four other men aged between 18 and 25 have previously been charged over their alleged roles in the double murder.
Police said in December they were still seeking a getaway driver and a shooter, who was seen on CCTV footage slipping before firing into the ute.