Jasveen Sangha, who admitted to running a "stash house" for illegal narcotics out of her home in the North Hollywood district of Los Angeles, pleaded guilty in September to five felony drug counts stemming from Perry's 2023 death.
Sangha, 42, a dual US-UK citizen, had faced a sentence of up to 65 years in prison.
Sangha stood at the podium on Wednesday just before she was sentenced and told the judge she wears her shame "like a jacket".
"These were not mistakes. They were horrible decisions," Sangha said, which "shattered people's lives and the lives of their family and friends".
US District Judge Sherilyn Garnett imposed a 15-year sentence, harsher than the penalties received by any of her four co-defendants in the case, including two physicians.
Federal prosecutors had recommended a 15-year prison term.
The defence had urged the judge to limit Sangha's sentence to time already served.
Sangha has been incarcerated since August 2024.
Perry was found by his live-in personal assistant floating face down and lifeless in a hot tub at his Los Angeles home on October 28, 2023.
He was 54.
Keith Morrison, Perry's stepfather and correspondent for NBC's Dateline, told the judge that he and Perry's mother Suzanne feel a "daily, grinding sadness and sorrow".
"There was a spark to that man I have never seen anywhere else," Morrison said.
"He should have had another act. Two more acts."
An autopsy report concluded Perry died from the "acute effects of ketamine," which combined with other factors in causing the actor to lose consciousness and drown.
Ketamine is a short-acting but potent anesthetic with hallucinogenic properties that is sometimes prescribed to treat depression and other psychological disorders.
It also has gained popularity for abuse as an illicit party drug.
Perry had publicly acknowledged decades of substance abuse that overlapped with the height of his fame playing the sardonic but charming Chandler Bing on the 1990s hit NBC television comedy Friends.
His death came a year after publication of Perry's memoir Friends, Lovers, and the Big Terrible Thing, which chronicled bouts with addiction to prescription painkillers and alcohol that he wrote had come close to ending his life more than once.
In the months before he died, Perry had claimed to have regained sobriety.
But according to federal law enforcement officials, Perry had been undergoing medically supervised ketamine infusions for depression and anxiety at a clinic where he became addicted to the drug.
When doctors there refused to increase his dosage, Perry turned to unscrupulous providers willing to exploit his drug dependency for their own financial benefit, authorities said.
Within weeks, he was dead from an overdose of ketamine supplied by Sangha, who was known to her customers on the street as the "Ketamine Queen".
Sangha acknowledged selling a total of 51 vials of ketamine to a go-between dealer, Erik Fleming, who in turn sold the doses to Perry through the actor's personal assistant, Kenneth Iwamasa.
It was Iwamasa, prosecutors said, who later injected Perry with at least three shots of ketamine from the vials Sangha had supplied, resulting in the actor's death.
As part of her deal with prosecutors, Sangha pleaded guilty to one count of maintaining a drug-involved premises plus three counts of illegal distribution of ketamine and one count of distributing ketamine resulting in death.
Sangha admitted then that she was aware that vials she sold to Fleming were intended for Perry.
She also admitted to selling ketamine to a person in August 2019 who died hours later from an overdose.
Fleming, Iwamasa and the two medical doctors charged in the case - Mark Chavez and Salvador Plasencia - have all pleaded guilty to federal drug offences in the case.
with AP
