Up to 60,000 fans will descend on Optus Stadium as Western Australia and Victoria lock horns in the first AFL State of Origin clash since 1999.
The concept has been widely backed by the AFL's biggest stars, with both WA and Victoria boasting loaded sides stacked with sublime talent.
Some critics have questioned how hard players will go given the injury risks and the fact the season proper hasn't even started.
Scott has no doubt players from WA and Victoria will be going all-out for victory - unlike some of the other exhibition games the AFL have put on over the past 20 years.
"I know there have been a couple of games that I think we would describe ... as a bit more Mickey Mouse over the last decade or so," Scott said.
"I think it's probably something like 25 years since this has been a really serious game.
"And I guess along with the honour that we all feel being asked to represent our state, it is that responsibility to actually build something bigger.
"We're not making any promises necessarily about what this could evolve into in the future, but we certainly don't want to do a disservice to it and have the people that might be questioning it at the moment feel vindicated.
"We're really confident that we can put on a good show."
Carlton star Patrick Cripps will captain WA, while Western Bulldogs counterpart Marcus Bontempelli will lead Victoria.
Scott has been pleased with the way both sides have bought in since the concept was confirmed last year.
"I've heard from both camps that we feel a responsibility to do this properly," Scott said.
"That was the first thing that we talked about when we were first approached - Bont and I had a conversation around this really early days.
"We had no interest in doing it if it wasn't taken seriously. So now we feel like we've got to deliver on that."
How a club would react if one of their players suffered a serious injury remains to be seen.
But Scott pointed out that players could just as easily injure themselves during a practice match, or have the bad luck of injuring something during training.
On Friday, star GWS midfielder Tom Green suffered a suspected ACL tear during an intra-club match.
"It's a terrible thing," Scott said in relation to Green's injury.
"No one feels anything but sympathy for GWS and Tom in particular.
"But it just does highlight that these things happen at this time of year, whether it's an inconsequential training session or State of Origin at Optus.
"These things are risks, but one that clearly all the players and the coaching staff have been more than happy to take."
Victoria will take a sublime midfield into the match featuring the likes of skipper Marcus Bontempelli, Bailey Smith, Caleb Serong, Matt Rowell, Nick Daicos, Zach Merrett, Zak Butters and Noah Anderson.
WA coach Dean Cox acknowledged his team were the underdogs, but he is confident they have the right balance to cause an upset.
"The calibre of the Victorian team and what they've done individually through their own clubs has been phenomenal," Cox said.
"Having said that though ... (our players) complement each other, and in their own rights have had unbelievable football careers as well."
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