It will be held at the Australian Institute of Sport in Canberra this Sunday.
Stella Butcher, Jock and Isobel Gordon and Logan Littmann were chosen from a capped squad of just 48 swimmers, after nominations from across the region were reviewed by SISA.
The Brophy meet is a major end‑of‑season event hosted annually by Swimming ACT, bringing together teams from the southern half of NSW, the ACT and the NSW Victorian border region.
It is a true test of versatility, with every swimmer competing in all four 50m strokes as well as a relay.
The Deni swimmers have put in a strong season of training and competition, progressing through club meets, school carnivals and district and Riverina levels, with some now preparing for State next month.
Logan, who competed at the AIS last year, said the experience left a big impression and described it as “a fantastic experience”.
The Deniliquin Swim Club, congratulated the four athletes on their selection.
“We wish them all the best in their preparation for the upcoming meet,” committee member Katie Barling said.
“We cannot wait to see what they achieve next.”