The deportees will start arriving in Congo this month, the Congolese government said in a statement, without further details on the date or the number of deportees expected.
It described the arrangement as a "temporary" one that reflects Congo's "commitment to human dignity and international solidarity".
It would come with zero costs to the government, with the US covering the needed logistics, it said.
The US has struck such third-country deportation deals with at least seven other African nations, many of them among countries hit the most by the Trump administration's policies that have restricted trade, aid and migration.
The Trump administration has spent at least $US40 million ($A58 million) to deport about 300 migrants to countries other than their own, according to a report released recently by the Democratic staff of the Senate Foreign Relations Committee.
Lawyers and activists have raised questions over the nature of the deals with countries in Africa and elsewhere.
Parts of Congo have been marred by armed conflict for decades.
The United Nations has warned of escalating violence, human rights atrocities and millions being displaced amid rebel clashes.
America's travel advice warns citizens to "reconsider travel to the Democratic Republic of the Congo" because of violent crime and armed conflict.
Several of the African nations that have signed such deals with the Trump administration have notoriously repressive governments and poor human rights records — including Eswatini, South Sudan and Equatorial Guinea.
A key bone of contention in many such agreements is that they involve many migrants with protection orders from a US immigration judge not to be returned to their home countries over major safety concerns.
Congo's government said no automatic transfer of the deportees is planned.
"Each situation will be subject to individual review in accordance with the laws of the Republic and national security requirements," the government said.
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