An evening drone strike on the closed Southern Bridge was the latest in a series of attacks since Thursday that forced the full or partial suspension of traffic across it and two other bridges spanning the vast Dnipro River.
Long traffic jams snaked through the city in the morning and evening as residents struggled to adapt to the almost constant Russian drone attacks on Kyiv in recent weeks.
Before the latest attack on the bridge, Mayor Vitali Klitschko held a city security council meeting to assess the risks, describing the situation in the city as "very dramatic".
More than one-third of the capital's three million residents lived on the east, or "left", bank of the Dnipro before Russia's 2022 invasion, but the vast majority work on the western, or "right", bank where most government institutions and companies are.
Earlier on Friday, one person was killed and two injured in a Russian drone strike that caused a fire on the upper floors of an apartment building, officials said.
In the northeastern city of Kharkiv, Ukraine's second-biggest, two people were killed and 32 wounded in a guided-bomb strike, according to the regional governor.
A senior Ukrainian official said the strikes on the bridges and other sensitive infrastructure appeared linked to an order by President Vladimir Putin last month to scrap constraints on Russia's air campaign.
The order was first reported by the Financial Times.
Memories of last winter, the worst of the war, are prominent in residents' minds after Russia launched what was seen in Ukraine as the first salvo of an expected winter bombing campaign against power facilities supplying the capital.
Russia has since summer launched dozens of fast and relatively cheap jet-powered drones a day at Ukraine, whose defences have struggled against them.
Russia's defence ministry said on Telegram its drones had hit a Kyiv bridge, a power station in the surrounding region, the southwestern port of Izmail and a cargo vessel. All targets were used for military purposes, it said.
Russian news agencies later quoted the ministry as saying further strikes during the day had hit a data centre in the Black Sea port of Mykolaiv and another vessel bound for Odesa.
In Russia, Ukrainian drones targeted the Lukoil refinery in Volgograd and another oil facility in Samara region, Ukraine's military said.
Ukraine's strikes on oil refineries in Russia, one of the world's leading oil producers, have cost Russia one per cent of its gross domestic product, Russian President Vladimir Putin has said. Long lines have formed at Russian petrol stations.
Foreign Minister Andrii Sybiha told reporters on Thursday that Poland, Belgium and Spain had agreed to supply 20mm rounds for cannons on Ukraine's F-16 jet fighters, one of its most effective tools for the fight against the new, faster drones.
He said Kyiv was anticipating a possible agreement on the supply of "several million" rounds of this ammunition in the near future, but did not specify from whom.
Sybiha also said Ukraine needed at least 300 Patriot interceptor missiles - the only weapon it can reliably use to bring down Russia's ballistic missiles - to have a minimum level of protection for the winter period.
Moscow is thought to be making 120 to 140 ballistic missiles each month, he said, with 600 already in its stocks.
