The attack on the port, which Ukraine's military said plunged the site into a blackout, followed two strikes earlier this week on a bridge linking the Russian-occupied Kherson region to the Black Sea peninsula, which Moscow seized in 2014.
Ukrainian President Volodymyr Zelenskiy said his country's forces struck several military and energy infrastructure sites, including a military factory that he said supplied components for Russian drones and missiles.
In a post on social media, Zelenskyy said Ukrainian FP-5 Flamingo long-range missiles had hit the facility in Cheboksary, located in the Chuvashiya region more than 900km from the frontline.
The attacks are part of a mounting Ukrainian campaign to target Russian logistics far behind the frontline of Moscow's four-year-long war, an effort analysts have said is helping slow its war machine.
The Kherson region bridge across southern Ukraine is a critical supply corridor for Russian forces as they attempt to grind forward along parts of the 1200km frontline, amid signs of new Ukrainian resistance.
Kyiv's drone forces said Ukrainian units had struck several key facilities at the Mariupol port, including energy and maintenance infrastructure, in an attack that has "significantly limited" the city's capacity as a logistics hub.
A video posted by Ukraine's 1st Azov Corps, which also participated in the operation, showed drone footage of ships, power stations and other structures coming under attack.
"Electrical substations, radar equipment, repair infrastructure, the control tower, and fuel and lubricant storage tanks were hit," it said in a statement, adding that a sanctioned cargo vessel was also damaged.
Ukraine's 1st Separate Assault Regiment said it had launched drone attacks on June 7 and 9 that struck the Chonhar bridge, one of two over-water crossings connecting Crimea to either Russian-occupied territory or Russia itself.
"We see all movements and totally control the enemy's repair works," it said on Facebook. "We are ready to make our long-range adjustments at any moment."
Earlier in the war, Ukraine repeatedly targeted the bridge across the Kerch Strait connecting western Crimea to Russia's Krasnodar region.
This week's attacks come after months of shifting battlefield dynamics in which Moscow's momentum has slowed to a crawl, partly a result of Ukrainian strikes on critical logistical targets, including on oil and military-industrial infrastructure inside Russia.
In a statement, Ukrainian open-source analysis group DeepState said Kyiv's "blockade" of Russian supply lines across the occupied south could further hamstring Moscow's battlefield efforts.
The attacks also send a powerful message, it added.
Writing on Telegram, Russian war blogger Yuri Baranchik said Ukraine's stepped-up strikes on logistics across the area show Kyiv had "caught up" with Moscow's capabilities.
with AP
