Scores were level early in the final quarter of Friday night's blockbuster following Crows forward Riley Thilthorpe's second goal of the night.
But buoyed by a thundering 55,010-strong crowd, Fremantle did what they've done all season -- blow a rival off the park with a devastating burst.
Michael Frederick started the run when he nailed a tough set shot after being tackled high.
Although Josh Treacy, Luke Jackson and Andrew Brayshaw missed their shots after that, Amiss bobbed up for his fifth goal of the night by snapping from the goalsquare.
And when Isaiah Dudley dodged and weaved his way through three Crows players before unleashing a successful snap, the margin was 22 points and it was game over.
Dockers ruckman Mason Cox rubbed it in by roughing up an opponent and then pointing to the scoreboard after kicking a goal in the dying minutes of the 16.16 (112) to 13.10 (88) win.
The triumph boosted Fremantle's record to 19-3, securing the club a second minor premiership to go with their 2013 efforts.
It also meant Fremantle will end the home-and-away season with a perfect 12-0 record at Optus Stadium.
"We've set our season up. That's the way I look at it," Fremantle coach Justin Longmuir said of winning the minor premiership, with his full focus still on guiding Fremantle to the ultimate prize.
"It's a good achievement. I'm really proud of the players of how they bounced back after last week.
"We've put ourselves in a good position."
Adelaide (14-8) now face a huge battle to snare a top-four berth, with the loss even leaving them vulnerable to slipping into the dreaded wildcard spots from seventh to 10th.
Amiss finished with 5.1 in a powerful display, Josh Treacy was huge with six contested marks but a wayward 1.4, Dudley kicked three goals, while Serong was influential with 29 disposals, 12 clearances, 536m gained and two goals.
Crows playmaker Izak Rankine racked up a monster 14 disposals in the opening term on the way to 39 possessions, 10 clearances, 717m gained and one goal.
Adelaide had an interesting lead-in to the match, with players forced to evacuate their hotel just hours before bounce down due to a fire alarm going off in their hotel.
Amiss missed an early set shot sitter from 15m out as Adelaide skipped out to a two-goal lead.
But Amiss soon made amends, nailing three other set shots for the term - from 50m, 40m and 35m - to give Fremantle a 13-point edge by quarter time.
Fremantle led by just five points at halftime, and the third quarter was a rollercoaster ride featuring four lead changes and five occasions when the scores were even.
Fremantle skipper Alex Pearce suffered a huge scare when his heavily-strapped left knee hyper-extend during a collision, leaving him hobbled for the next couple of minutes.
The action was fierce and fast, but it was Fremantle who produced more of the memorable moments.
Treacy hurt himself while completing a team-lifting tackle on Max Michalanney.
The Fremantle powerhouse dusted himself off after a few deep breaths and kicked a goal moments later.
Serong nailed a goal from just inside the centre square following a dazzling series of handballs from the Dockers.
And when Brayshaw dribbled one through with the outside of his right boot, Fremantle turned for home with a seven-point edge.
The Dockers kicked five goals to three in a powerful final term to wrap up top spot on the ladder with one round to spare.
"When it was in the balance, we just made some crucial errors," Adelaide coach Matthew Nicks said.
"Some of it was execution, just skill, handballs, missed handballs, and we got punished, which the best teams in the competition do."
